Experience in 1,000 liver transplants under cyclosporine-steroid therapy: a survival report.

SINCE the first human liver transplantation in Denver on March 1, 1963, numerous refinements in surgical techniques and in perioperative care have been made, the mechanism of graft rejection has been more precisely understood, and safer and more effective immunosuppressive agents have been discovered. I . 3 Now, in 1987, it is well accepted that liver transplantation is often the only effective therapy for many advanced liver. diseases. We will report here, as a landmark of our continuing efforts, the survival of patients with various end-stage liver diseases after liver transplantation from our own experience in 1,000 hepatic homograft recipients under cyclosporine-steroid therapy.